Induced pluripotent stem cell (iPSC) derived cell types are increasingly employed as in vitro
model systems for drug discovery. For these studies to be meaningful, it is important to …

Objective Gain of function variants in the sodium‐activated potassium channel KCNT1 have
been associated with pediatric epilepsy disorders. Here, we systematically examine a …

Pelizaeus-Merzbacher disease (PMD) is a family of X-linked, dysmyelinating disorders of
the central nervous system (CNS). Patients with PMD present with nystagmus in the first few …

Over the course of the last decade, the biopharmaceutical industry has slowly adopted
human inducible pluripotent stem cell (hiPSC) technology to enable the development of …

Alzheimer’s disease (AD), the most prevalent form of dementia worldwide, affects a growing
proportion of the elderly and poses a significant societal burden. Pathological hallmarks …

BACKGROUND: There is an extensive literature describing how stress disturbs cognitive
processing and can exacerbate psychiatric disorders. There is, however, an insufficient …

… We thank Sandi Engle for the suggestion of using the inflammation index. We thank Wen
Yun Sun for expert assistance with PCR genotyping, and James Cornelius for expert …

Asthma remains one of the most important challenges to pediatric public health in the US. A
large majority of children with persistent and chronic asthma demonstrate aeroallergen …

… We thank Bunny Cotleur, Attila Fabian and Matt Gormley for flow cytometry and cell sorting
help; Joe Amatucci for antibody purification; Jianxin Hu and Sandi Engle for generating the …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by CAG
trinucleotide repeat expansions in exon 1 of the HTT gene. In addition to germline CAG …