User profiles for Sandra Codlin
 | sandra codlinVerified email at ucl.ac.uk Cited by 2222 |
[HTML][HTML] Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells
Data on absolute molecule numbers will empower the modeling, understanding, and
comparison of cellular functions and biological systems. We quantified transcriptomes and …
comparison of cellular functions and biological systems. We quantified transcriptomes and …
[HTML][HTML] A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice
…, C Walker, L Hulme, E Bernhard, S Codlin… - Nature …, 2014 - nature.com
DNA double-strand break (DSB) repair is a highly regulated process performed predominantly
by non-homologous end joining (NHEJ) or homologous recombination (HR) pathways. …
by non-homologous end joining (NHEJ) or homologous recombination (HR) pathways. …
The genomic and phenotypic diversity of Schizosaccharomyces pombe
Natural variation within species reveals aspects of genome evolution and function. The
fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but …
fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but …
TORC 1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
Target of rapamycin complex 1 ( TORC 1) is implicated in growth control and aging from yeast
to humans. Fission yeast is emerging as a popular model organism to study TOR signaling…
to humans. Fission yeast is emerging as a popular model organism to study TOR signaling…
CLN6, which is associated with a lysosomal storage disease, is an endoplasmic reticulum protein
The neuronal ceroid lipofuscinoses (NCLs) are severe inherited neurodegenerative disorders
affecting children. In this disease, lysosomes accumulate autofluorescent storage material …
affecting children. In this disease, lysosomes accumulate autofluorescent storage material …
A function retained by the common mutant CLN3 protein is responsible for the late onset of juvenile neuronal ceroid lipofuscinosis
C Kitzmüller, RL Haines, S Codlin… - Human molecular …, 2008 - academic.oup.com
The neuronal ceroid lipofuscinoses (NCLs) are common neurodegenerative disorders of
childhood and are classified as lysosomal storage diseases since affected cells exhibit …
childhood and are classified as lysosomal storage diseases since affected cells exhibit …
LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq
Both canonical and alternative splicing of RNAs are governed by intronic sequence elements
and produce transient lariat structures fastened by branch points within introns. To map …
and produce transient lariat structures fastened by branch points within introns. To map …
btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis
Y Gachet, S Codlin, JS Hyams… - Journal of cell …, 2005 - journals.biologists.com
We have cloned the Schizosaccharomyces pombe homologue of the human Batten disease
gene, CLN3. This gene, btn1, encodes a predicted transmembrane protein that is 30% …
gene, CLN3. This gene, btn1, encodes a predicted transmembrane protein that is 30% …
Natural genetic variation impacts expression levels of coding, non‐coding, and antisense transcripts in fission yeast
M Clément‐Ziza, FX Marsellach, S Codlin… - Molecular systems …, 2014 - embopress.org
Our current understanding of how natural genetic variation affects gene expression beyond
well‐annotated coding genes is still limited. The use of deep sequencing technologies for …
well‐annotated coding genes is still limited. The use of deep sequencing technologies for …
[PDF][PDF] The GATA transcription factor Gaf1 represses tRNAs, inhibits growth, and extends chronological lifespan downstream of fission yeast TORC1
…, S Gonzalez, O Hillson, E Tunnacliffe, S Codlin… - Cell Reports, 2020 - cell.com
Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition
of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent …
of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent …