Cancer testis antigens (CTA) are a large family of tumor-associated antigens expressed in
human tumors of different histological origin, but not in normal tissues except for testis and …

Endoglin (CD105) is a cell membrane glycoprotein over‐expressed on highly proliferating
endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within …

In the last three decades huge efforts have been made to characterize genetic defects
responsible for cancer development and progression, leading to the comprehensive identification …

Cancer/testis antigens (CTA) are suitable targets for immunotherapy of human malignancies,
and clinical trials are mainly focusing on MAGE-A3. However, the heterogeneous …

Increasing evidence suggests that endoglin (CD105) is a new powerful marker of
neovascularization in solid malignancies; thus, using breast cancer as a model, we investigated …

Purpose: Limited therapeutic options are presently available for advanced renal cell
carcinoma (RCC). This study was designed to define the clinical potential of the DNA …

The immunogenic potential of melanoma cells and their recognition by the host's cytotoxic
cells depends on the presence and on the level of expression of human leukocyte antigen (…

Epigenetic regulation allows heritably modulating gene expression profiles without
modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns …

Continuously improving knowledge of the fine mechanisms regulating cross-talk between
immune cells, and of their multi-faceted interactions with cancer cells, has prompted the …

Association with hypomethylating agents is a promising strategy to improve the efficacy of
immune checkpoint inhibitors-based therapy. The NIBIT-M4 was a phase Ib, dose-escalation …