Long-chain fatty acyl-CoA esters are key intermediates in numerous lipid metabolic pathways,
and recognized as important cellular signaling molecules. The intracellular flux and …

Advances in mass spectrometry-based lipidomics have in recent years prompted efforts to
standardize the annotation of the vast number of lipid molecules that can be detected in …

Neuronal activity causes use-dependent decline in protein function. However, it is unclear
how this is coupled to local quality control mechanisms. We show in Drosophila that the …

The interphase nuclear envelope (NE) is extensively remodeled during nuclear pore complex
(NPC) insertion. How this remodeling occurs and why it requires Torsin ATPases, which …

TOR1A/TorsinA mutations cause two incurable diseases: a recessive congenital syndrome
that can be lethal, and a dominantly-inherited childhood-onset dystonia (DYT-TOR1A). …

Total fatty acid analysis is a routine method in many areas, including lipotyping of individuals
in personalized medicine, analysis of foodstuffs, and optimization of oil production in …

Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1,
and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular …

Reliable, cost-effective, and gold-standard absolute quantification of non-esterified cholesterol
in human plasma is of paramount importance in clinical lipidomics and for the monitoring …

For more than ten years the nematode Caenorhabditis elegans has proven to be a valuable
model for studies of the host response to various bacterial and fungal pathogens. When …

The acyl-CoA binding protein (ACBP) plays a key role in chaperoning long-chain acyl-CoAs
into lipid metabolic processes and acts as an important regulatory hub in mammalian …