Herpes simplex virus (HSV) encodes a ribonucleotide reductase consisting of two subunits (140
and 38 kilodaltons) whose genes map to coordinates 0.56 to 0.60 on the viral genome. …

During replication of herpes simplex virus type 1 (HSV-1), viral DNA is synthesized in the
infected cell nucleus, where DNA-free capsids are also assembled. Genome-length DNA …

Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis—UL9
(origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (…

Herpes simplex virus type 1 encodes a ribonucleotide reductase (RR) consisting of two
subunits (140 and 38 kDa) whose genes map to coordinates 0.56 to 0.60 on the viral genome. …

Herpes simplex virus type 1 (HSV-1) DNA replication is associated with nuclear domains
called ND10, which contain host recombination proteins such as RPA, RAD51, and NBS1 and …

In an earlier report, we described a DNA helicase that is specifically induced upon infection
of Vero cells with herpes simplex virus 1. We have purified this enzyme to near homogeneity …

Mitochondria have crucial roles in the life and death of mammalian cells, and help to
orchestrate host antiviral defences. Here, we show that the ubiquitous human pathogen herpes …

The herpes simplex virus type 1 genome (160 kilobases) contains three origins of DNA
synthesis: two copies of ori S located within the repeated sequences flanking the short unique …

Many viruses and bacteriophage utilize chaperone systems for DNA replication and viral
morphogenesis. We have previously shown that in the herpes simplex virus type 1 (HSV-1)-…

Packaging of DNA into preformed capsids is a fundamental early event in the assembly of
herpes simplex virus type 1 (HSV-1) virions. Replicated viral DNA genomes, in the form of …