[HTML][HTML] Metagenomic analysis of the microbiota from the crop of an invasive snail reveals a rich reservoir of novel genes

…, RB Flatschart, A Glogauer, SMN Scapin… - PLoS …, 2012 - journals.plos.org
The shortage of petroleum reserves and the increase in CO 2 emissions have raised global
concerns and highlighted the importance of adopting sustainable energy sources. Second-…

[HTML][HTML] Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion

…, TCRG Vieira, MPB Gomes, LP Rangel, SMN Scapin… - Methods, 2011 - Elsevier
The concept that transmissible spongiform encephalopathies (TSEs) are caused only by
proteins has changed the traditional paradigm that disease transmission is due solely to an …

The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform

SMN Scapin, FRG Carneiro, AC Alves… - Journal of structural …, 2006 - Elsevier
Rab GTPases constitute the largest family of small monomeric GTPases, including over 60
members in humans. These GTPases share conserved residues related to nucleotide binding …

Self-assembly and structural characterization of Echinococcus granulosus antigen B recombinant subunit oligomers

KM Monteiro, SMN Scapin, MVAS Navarro… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Echinococcus granulosus antigen B is an oligomeric protein of 120–160 kDa composed by
8-kDa (AgB8) subunits. Here, we demonstrated that the AgB8 recombinant subunits AgB8/1, …

Formation of subvisible particles in commercial insulin formulations

…, TS Araújo, M da Silva Almeida, SMN Scapin… - Colloids and Surfaces B …, 2022 - Elsevier
The conformation and assembly of insulin are sensitive to physical and chemical variables.
Insulin can misfold and form both amorphous and amyloid aggregates. Localized cutaneous …

Biophysical characterization of two commercially available preparations of the drug containing Escherichia coli L-Asparaginase 2

TS de Araújo, SMN Scapin, W de Andrade… - Biophysical …, 2021 - Elsevier
The hydrolysis of asparagine and glutamine by L-asparaginase has been used to treat acute
lymphoblastic leukemia for over four decades. Each L-asparaginase monomer has a long …

Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation

…, TS de Araújo, BM Silva, LP Icart, SMN Scapin… - Biophysical …, 2023 - Elsevier
All clinically-used asparaginases convert L-asparagine (L-Asn) to l-aspartate (L-Asp) and l-glutamine
(L-Gln) to L-glutamate (L-Glu), which has been useful in reducing bioavailable …

Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and Sporothrix spp

…, G Santos-Silva, S Scapin… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
The new complexes Zn(ITZ) 2 Cl 2 (1) and Zn(ITZ) 2 (OH) 2 (2) were synthetized by a reaction
of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were …

Comparative proteomics of saliva of healthy and gingivitis individuals from Rio de Janeiro

…, Y Bacila Sade, SM Naressi Scapin… - PROTEOMICS …, 2023 - Wiley Online Library
Purpose In this work, we identified human and bacterial proteomes in the saliva from volunteers
with gingivitis or healthy. Experimental Design The reported population consisted of 18 …

Whey milk proteomics from Schistosoma mansoni–infected mice reveals proteins involved in immunomodulation of the offspring

GCR de Holanda, IL de Lima, SMN Scapin… - Parasitology …, 2020 - Springer
Milk from schistosomotic mothers can modulate the immune response of their offspring.
However, its characterization and potential of modulating immunity has not yet been fully …