Protein degradation is essential for maintaining cellular homeostasis. The proteasome is
the central enzyme responsible for non-lysosomal protein degradation in eukaryotic cells. …

Human tryptase, a mast-cell-specific serine proteinase that may be involved in causing
asthma and other allergic and inflammatory disorders 1 , 2 , 3 , is unique in two respects: it is …

The Database of Protein Disorder (DisProt, URL: www.disprot.org ) has been significantly
updated and upgraded since its last major renewal in 2007. The current release holds …

Rapid and controlled clot formation is achieved through sequential activation of circulating
serine proteinase precursors on phosphatidylserine-rich procoagulant membranes of …

The Database of Protein Disorder (DisProt, URL: https://disprot.org ) provides manually curated
annotations of intrinsically disordered proteins from the literature. Here we report recent …

Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural
motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick …

The vanadium-containing chloroperoxidase from the fungus Curvularia inaequalis is
heterologously expressed to high levels in the yeast Saccharomyces cerevisiae. Characterization …

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org ) is the
major repository of manually curated annotations of intrinsically disordered proteins and …

Background The characterization of the structural features that account for the high
thermostability of some proteins is of great scientific and biotechnological interest. Proteins from …

Biliverdin IXβ reductase (BVR-B) catalyzes the pyridine nucleotide-dependent production of
bilirubin-IXβ, the major heme catabolite during early fetal development. BVR-B displays a …