Gut microbiota is involved in obesity, metabolic syndrome and the progression of nonalcoholic
fatty liver disease (NAFLD). It has been recently suggested that the flavonoid quercetin …

Scope Flavonoids and related compounds seem to have favorable effects on nonalcoholic
fatty liver disease (NAFLD) progression, although the exact mechanisms implicated are …

Liver fatty acid binding protein (FABP1) prevents lipotoxicity of free fatty acids and regulates
fatty acid trafficking and partition. Our objective is to investigate the transcription factors …

Motivation Drug repositioning has been proposed as an effective shortcut to drug discovery.
The availability of large collections of transcriptional responses to drugs enables …

Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome,
is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis …

There is experimental evidence that some antioxidant flavonoids show therapeutic potential
in the treatment of hepatitis C through inhibition of hepatitis C virus (HCV) replication. We …

Molecular mechanisms contributing to hepatitis C virus (HCV)-associated steatosis are not
well established, although HCV gene expression has been shown to alter host cell cholesterol…

The MiT/TFE family of transcription factors (MITF, TFE3, and TFEB), which control transcriptional
programs for autophagy and lysosome biogenesis have emerged as regulators of …

Background: Lysosomotropic molecules are taken up into lysosomes in vitro and in vivo.
Many drugs approved for clinical medicine are lysosomotropic agents, characterized by …

The TRA nsport Protein Particle ( TRAPP ) complex controls multiple membrane trafficking
steps and is strategically positioned to mediate cell adaptation to diverse environmental …