Image‐based systems biology of infection
A Medyukhina, S Timme, Z Mokhtari… - Cytometry Part …, 2015 - Wiley Online Library
The successful treatment of infectious diseases requires interdisciplinary studies of all
aspects of infection processes. The overarching combination of experimental research and …
aspects of infection processes. The overarching combination of experimental research and …
Feasibility of SARS-CoV-2 surveillance testing among children and childcare workers at German day care centers: a nonrandomized controlled trial
…, P Rudolph, V Rücker, J Wallstabe, S Timme… - JAMA Network …, 2022 - jamanetwork.com
Importance Closure of day care centers has been implemented globally to contain the
COVID-19 pandemic but has negative effects on children’s health and psychosocial well-being. …
COVID-19 pandemic but has negative effects on children’s health and psychosocial well-being. …
Acceptance of different self-sampling methods for semiweekly SARS-CoV-2 testing in asymptomatic children and childcare workers at German day care centers: a …
…, C Bauer, D Gierszewski, J Bendig, S Timme… - JAMA Network …, 2022 - jamanetwork.com
Importance Closure of day care centers (DCCs) to contain the COVID-19 pandemic has
been associated with negative effects on children’s health and well-being. Objective To …
been associated with negative effects on children’s health and well-being. Objective To …
[HTML][HTML] Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections
C Saffer, S Timme, P Rudolph, MT Figge - NPJ Systems Biology and …, 2023 - nature.com
The immune system has to fight off hundreds of microbial invaders every day, such as the
human-pathogenic fungus Aspergillus fumigatus. The fungal conidia can reach the lower …
human-pathogenic fungus Aspergillus fumigatus. The fungal conidia can reach the lower …
[HTML][HTML] Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions
T Lehnert, S Timme, J Pollmächer, K Hünniger… - Frontiers in …, 2015 - frontiersin.org
Opportunistic fungal pathogens can cause bloodstream infection and severe sepsis upon
entering the blood stream of the host. The early immune response in human blood comprises …
entering the blood stream of the host. The early immune response in human blood comprises …
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
…, EL Priest, G Zhurgenbayeva, N Jablonowski, S Timme… - Mbio, 2024 - Am Soc Microbiol
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal
candidiasis, which is commonly observed in human immunodeficiency virus infected patients, …
candidiasis, which is commonly observed in human immunodeficiency virus infected patients, …
[HTML][HTML] Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs
J Pollmächer, S Timme, S Schuster, AA Brakhage… - Scientific reports, 2016 - nature.com
Microbial invaders are ubiquitously present and pose the constant risk of infections that are
opposed by various defence mechanisms of the human immune system. A tight regulation of …
opposed by various defence mechanisms of the human immune system. A tight regulation of …
[HTML][HTML] Hybrid agent-based modeling of Aspergillus fumigatus infection to quantitatively investigate the role of pores of Kohn in human alveoli
M Blickensdorf, S Timme, MT Figge - Frontiers in Microbiology, 2020 - frontiersin.org
The healthy state of an organism is constantly threatened by external cues. Due to the daily
inhalation of hundreds of particles and pathogens, the immune system needs to constantly …
inhalation of hundreds of particles and pathogens, the immune system needs to constantly …
[HTML][HTML] Comparative assessment of aspergillosis by virtual infection modeling in murine and human lung
M Blickensdorf, S Timme, MT Figge - Frontiers in Immunology, 2019 - frontiersin.org
Aspergillus fumigatus is a ubiquitous opportunistic fungal pathogen that can cause severe
infections in immunocompromised patients. Conidia that reach the lower respiratory tract are …
infections in immunocompromised patients. Conidia that reach the lower respiratory tract are …
[HTML][HTML] Predictive virtual infection modeling of fungal immune evasion in human whole blood
MTE Prauße, T Lehnert, S Timme, K Hünniger… - Frontiers in …, 2018 - frontiersin.org
Bloodstream infections by the human-pathogenic fungi Candida albicans and Candida
glabrata increasingly occur in hospitalized patients and are associated with high mortality rates. …
glabrata increasingly occur in hospitalized patients and are associated with high mortality rates. …