Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown.
Here, we find that sedentary but not active humans display an age-related decline in the …

PURPOSE: We studied survival rate, prognostic factors, and causes of death in patients with
systemic lupus erythematosus (SLE), particularly focusing on the influence of disease …

The histologic features of aging muscle suggest that denervation contributes to atrophy, that
immobility accelerates the process, and that routine exercise may protect against loss of …

Objective: To evaluate traditional and non-traditional risk factors for subclinical atherosclerosis
in systemic lupus erythematosus (SLE). Methods: A prospective cohort of 78 patients with …

Introduction Disuse atrophy may not only arise from a reduction in mechanical loading but
also from muscle denervation and neuromuscular junction damage, triggered by inactivity [1 , …

Aging is usually accompanied by a significant reduction in muscle mass and force. To
determine the relative contribution of inactivity and aging per se to this decay, we compared …

Contrary to general expectation, in humans, we have recently shown that after complete conus
cauda lesion, the lower motoneuron denervated myofibers may survive several years. In …

A growing body of experimental and clinical evidence supports the pivotal role of infections
in the induction or exacerbation of systemic lupus erythematosus (SLE). Infections can be …

Background. Spinal cord injury causes muscle wasting and loss of function, which are
especially severe after complete and permanent damage to lower motor neurons. In a previous …

Recent studies have correlated physical activity with a better prognosis in cachectic patients,
although the underlying mechanisms are not yet understood. In order to identify the …