Searching for original natural products by molecular networking: Detection, isolation and total synthesis of chloroaustralasines
…, D Touboul, F Roussi, M Litaudon, S Desrat - Organic Chemistry …, 2018 - pubs.rsc.org
With the aim of isolating structurally original natural products, a molecular networking (MN)-based
prioritisation approach has been developed and applied to a collection of 292 plant …
prioritisation approach has been developed and applied to a collection of 292 plant …
Intramolecular imino Diels− Alder reaction: progress toward the synthesis of uncialamycin
S Desrat, P van de Weghe - The Journal of Organic Chemistry, 2009 - ACS Publications
… Sandy Desrat … Sandy Desrat - EA Substances Lichéniques et Photoprotection, Faculté
des Sciences Biologiques et Pharmaceutiques, Université de Rennes 1, 2 avenue du Prof …
des Sciences Biologiques et Pharmaceutiques, Université de Rennes 1, 2 avenue du Prof …
Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A
…, L Eloy, E Jacquet, J Bignon, J Wiels, S Desrat… - European journal of …, 2018 - Elsevier
Thirty analogues of natural meiogynin A, a pan-Bcl-2 inhibitor, were prepared in order to
elaborate cytotoxic compounds on specific cancer cells overexpressing one or more proteins of …
elaborate cytotoxic compounds on specific cancer cells overexpressing one or more proteins of …
[HTML][HTML] Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor
ORPphilins are bioactive natural products that strongly and selectively inhibit the growth of
some cancer cell lines and are proposed to target intracellular lipid-transfer proteins of the …
some cancer cell lines and are proposed to target intracellular lipid-transfer proteins of the …
Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins
S Desrat, C Remeur, F Roussi - Organic & biomolecular chemistry, 2015 - pubs.rsc.org
The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a
chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven …
chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven …
Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein
Schweinfurthins (SWs) are naturally occurring prenylated stilbenes with promising anticancer
properties. They act through a novel mechanism of action similar to that of other families of …
properties. They act through a novel mechanism of action similar to that of other families of …
From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins
S Desrat, C Remeur, C Geny, G Riviere… - Chemical …, 2014 - pubs.rsc.org
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL
and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was …
and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was …
Isolation of Picrotoxanes from Austrobuxus carunculatus Using Taxonomy-Based Molecular Networking
F Olivon, P Retailleau, S Desrat… - Journal of Natural …, 2020 - ACS Publications
A unique collection of 292 extracts from 107 New Caledonian Euphorbiaceae species sensu
lato was profiled by LC-MS 2 and the metabolite content organized by molecular networking…
lato was profiled by LC-MS 2 and the metabolite content organized by molecular networking…
Structurally Diverse Diterpenoids from Sandwithia guyanensis
Bioassay-guided fractionation of an EtOAc extract of the trunk bark of Sandwithia guyanensis,
using a chikungunya virus (CHIKV)-cell-based assay, afforded 17 new diterpenoids 1–17 …
using a chikungunya virus (CHIKV)-cell-based assay, afforded 17 new diterpenoids 1–17 …
[HTML][HTML] NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal …
…, V Dumontet, A Malzert-Fréon, S Desrat… - Biomedicine & …, 2022 - Elsevier
The overexpression of antiapoptotic members (BCL-2, BCL-xL, MCL-1, etc.) of the BCL-2
family contributes to tumor development and resistance to chemotherapy or radiotherapy. …
family contributes to tumor development and resistance to chemotherapy or radiotherapy. …