Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the
lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles. The …

The hypoxic ventilatory response (HVR) is critical to breathing and thus oxygen supply to
the body and is primarily mediated by the carotid bodies. Here we reveal that carotid body …

Elevated levels of circulating cobalt ions have been linked with a wide range of systemic
complications including neurological, endocrine, and cardiovascular symptoms. Case reports of …

AMPK has been reported to facilitate hypoxic pulmonary vasoconstriction but, paradoxically,
its deficiency precipitates pulmonary hypertension. Here we show that AMPK-α1/α2 …

We recently demonstrated that the hypoxic ventilatory response (HVR) is facilitated by the
AMP-activated protein kinase (AMPK) in catecholaminergic neural networks that likely lie …

The hypoxic ventilatory response (HVR) is markedly attenuated by AMPK-α1 deletion
conditional on the expression of Cre-recombinase in tyrosine hydroxylase (TH) expressing cells, …

Functional magnetic resonance imaging (fMRI) suggests that the hypoxic ventilatory response
is facilitated by the AMP-activated protein kinase (AMPK), not at the carotid bodies, but …

Aims Elevated blood cobalt levels secondary to metal-on-metal (MoM) hip arthroplasties are
a suggested risk factor for developing cardiovascular complications including …

Background: Age influences outcome of sepsis and septic shock. The mechanism of this age-dependent
vulnerability to sepsis remains largely unknown. Because much of the mortality …

During hypoxia, ventilatory adjustments are critical to the maintenance of adequate oxygen (O
2 ) delivery, for example during sleep or ascent to altitude (1). We recently demonstrated …