A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4
SW Messenger, SS Woo, Z Sun, TFJ Martin - Journal of Cell Biology, 2018 - rupress.org
Cancer cells secrete copious amounts of exosomes, and elevated intracellular Ca 2+ is
critical for tumor progression and metastasis, but the underlying cellular mechanisms are …
critical for tumor progression and metastasis, but the underlying cellular mechanisms are …
Lipoteichoic acid and muramyl dipeptide synergistically induce maturation of human dendritic cells and concurrent expression of proinflammatory cytokines
Maturation is an important process by which dendritic cells (DC) develop the potent antigen-presentation
capacity necessary for efficient activation of adaptive immunity. Here, we have …
capacity necessary for efficient activation of adaptive immunity. Here, we have …
Induction of IL-8 expression by bacterial flagellin is mediated through lipid raft formation and intracellular TLR5 activation in A549 cells
J Im, JH Jeon, MK Cho, SS Woo, SS Kang, CH Yun… - Molecular …, 2009 - Elsevier
We investigated the mechanism for the induction of a chemokine, IL-8, by bacterial flagellins
in the human alveolar type II epithelial cell line, A549. Bacterial flagellin induced expression …
in the human alveolar type II epithelial cell line, A549. Bacterial flagellin induced expression …
Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-κB and AP-1 in PMA-differentiated THP-1 cells
SS Kang, SS Woo, J Im, JS Yang, CH Yun… - International …, 2007 - Elsevier
Human placenta is a rich reservoir of diverse bioactive molecules with therapeutic potential
against certain diseases such as immune disorders. In the present study, we investigated the …
against certain diseases such as immune disorders. In the present study, we investigated the …
Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles
SS Woo, DJ James, TFJ Martin - Molecular biology of the cell, 2017 - Am Soc Cell Biol
Munc13-4 is a Ca 2+ -dependent SNARE (soluble N-ethylmaleimide–sensitive factor
attachment protein receptor)- and phospholipid-binding protein that localizes to and primes …
attachment protein receptor)- and phospholipid-binding protein that localizes to and primes …
Peptidoglycan-mediated IL-8 expression in human alveolar type II epithelial cells requires lipid raft formation and MAPK activation
IS Cheon, SS Woo, SS Kang, J Im, CH Yun… - Molecular …, 2008 - Elsevier
Staphylococcus aureus, a major sepsis-causing Gram-positive bacterium, invades pulmonary
epithelial cells and causes lung diseases. In the lung, alveolar type II epithelial cells play …
epithelial cells and causes lung diseases. In the lung, alveolar type II epithelial cells play …
A food-born heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP), suppresses tumor necrosis factor-α expression in lipoteichoic acid …
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine with strong
carcinogenic and mutagenic potential, is created abundantly in the overcooking of meat and …
carcinogenic and mutagenic potential, is created abundantly in the overcooking of meat and …
Bacillus anthracis lethal toxin attenuates lipoteichoic acid-induced maturation and activation of dendritic cells through a unique mechanism
J Yang, SS Woo, YH Ryu, CH Yun, MH Cho… - Molecular …, 2009 - Elsevier
Lethal toxin (LT), produced by the gram-positive bacterium Bacillus anthracis, was identified
as a major etiologic agent causing anthrax due to its strong immunotoxicity. Gram-positive …
as a major etiologic agent causing anthrax due to its strong immunotoxicity. Gram-positive …
[HTML][HTML] Small molecules that inhibit the late stage of Munc13-4–dependent secretory granule exocytosis in mast cells
…, DJ James, MQ Serrano, J Esquibel, SS Woo… - Journal of Biological …, 2018 - ASBMB
Ca 2+ -dependent secretory granule fusion with the plasma membrane is the final step for
the exocytic release of inflammatory mediators, neuropeptides, and peptide hormones. …
the exocytic release of inflammatory mediators, neuropeptides, and peptide hormones. …
Correction: A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4
SW Messenger, SS Woo, Z Sun… - The Journal of Cell …, 2019 - ncbi.nlm.nih.gov
Figure S1. Characterization of Ca2+-and Munc13-4–dependent released exosomes.(A)
Culture media supernatants (as in Fig. 1 B) from untreated or ionomycin-treated MDA-MB-231 …
Culture media supernatants (as in Fig. 1 B) from untreated or ionomycin-treated MDA-MB-231 …