Cell migration is a prerequisite for cancer invasion and metastasis, suggesting cell motility
as a potential therapeutic target for cancer treatment. A synthetic library was screened to …

Nuclear factor-κB (NF-κB) and the signaling pathways that regulate its activity have become
a focal point for intense drug discovery and development efforts. NF-κB regulates the …

Compounds 4a–j and 5 were synthesized by cyclocondensation of 3a–j and hydrazine and
showed significant LDL-antioxidant activities in the TBARS assay, the lag time of conjugated …

Reactive oxygen species (ROS) are inevitably generated in aerobic organisms as by-products
of normal metabolism or as the result of defense and development. ROS readily oxidize …

G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs),
implicated in neutrophil migration and inflammatory cytokine production. However, the …

Biofilm production has been implicated as a potential virulence factor of some Candida
species responsible for catheter-related fungemia in patients receiving parenteral nutrition. We …

Bacterial enoyl-acyl carrier protein reductase (FabI) is a promising novel antibacterial target.
We isolated a new class of FabI inhibitor from Penicillium chrysogenum, which produces …

A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of
Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N …

… Author links open overlay panel Tae-Sook Jeong 1 , Kyung Soon Kim 1 , So-Jin An ,
Kyung-Hyun Cho , Sangku Lee , Woo Song Lee … CW Joyce, GS Shelness, MA Davis, RG …

A series of cinnamic acid derivatives were synthesized and their biological abilities on lipoprotein
metabolism were examined. Among the tested compounds, 4-hydroxycinnamic acid (l-…