Fibroblast-collagen matrix culture has facilitated the analysis of cell physiology under
conditions that more closely resemble an in vivo-like environment compared to conventional 2-…

Connective tissues provide mechanical support and frameworks for the other tissues of the
body. Type 1 collagen is the major protein component of ordinary connective tissue, and …

Mechanical and physical features of the extracellular environment dramatically impact cell
shape. Fibroblasts interacting with 3D relaxed collagen matrices appear much different from …

Fibroblast-3D collagen matrix culture provides a model system to analyze cell physiology
under conditions that more closely resemble tissue than conventional 2D cell culture. Previous …

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with deficits in
cognition and synaptic plasticity. While accumulation of amyloid β (Aβ) and hyper-phosphorylation …

Variants in the APOE gene region may explain ethnic differences in the association of
Alzheimer’s disease (AD) with ε4. Ethnic differences in allele frequencies for three APOE region …

Increasing matrix stiffness caused by the extracellular matrix (ECM) deposition surrounding
cancer cells is accompanied by epithelial–mesenchymal transition (EMT). Here, we show …

Epidermal growth factor (EGF) plays a critical role in fibroblasts by stimulating the production
of collagen and supports cell renewal through the interaction between keratinocytes and …

Fibroblast three-dimensional collagen matrix culture provides a tissue-like model that can be
used to analyze cell form and function. The physiological agonists platelet-derived growth …

Trichostatin A (TSA), an inhibitor of histone deacetylase, is a well-known antitumor agent
that effectively and selectively induces tumor growth arrest and apoptosis. Recently, it was …