Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of
self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict …

How distal regulatory elements control gene transcription and chromatin topology is not
clearly defined, yet these processes are closely linked in lineage specification during …

Transcriptional regulatory mechanisms likely contribute to the etiology of inflammatory bowel
disease (IBD), as genetic variants associated with the disease are disproportionately found …

The NF-κB protein p65/RelA plays a pivotal role in coordinating gene expression in response
to diverse stimuli, including viral infections. At the chromatin level, p65/RelA regulates …

Background Pre-diagnosis attrition needs to be addressed urgently if we are to make progress
in improving MDR-TB case detection and achieve universal access to MDR-TB care. We …

Metazoan chromosomes are organized into discrete spatial domains (TADs), believed to
contribute to the regulation of transcriptional programs. Despite extensive correlation between …

Fully delineating the protein interactome by which AMPK regulates adaptive survival responses
to energy/metabolic stress, either via epigenetic gene regulation or other mechanisms, …

Metazoan chromosomes are organized into discrete domains (TADs), believed to contribute
to the regulation of transcriptional programs. Despite extensive correlation between TAD …

EcoDam is an adenine-N6 DNA methyltransferase that methylates the GATC sites in the
Escherichia coli genome. We have changed the target specificity of EcoDam from GATC to …

The crystal structure of the Escherichia coli DNA adenine methyltransferase (EcoDam) in a
binary complex with the cofactor product S-adenosyl-l-homocysteine (AdoHcy) unexpectedly …