Factor H (fH), a key alternative complement pathway regulator, is a cofactor for factor I–mediated
cleavage of C3b. fH consists of 20 short consensus repeat (SCR) domains. Sialic acid …

Neisseria meningitidis binds factor H (fH), a key regulator of the alternative complement
pathway. A∼ 29 kD fH-binding protein expressed in the meningococcal outer membrane was …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

Syphilis Over the past two decades, the incidence of syphilis has increased sharply. The
courses of both untreated and treated disease can be unpredictable. This review presents …

Neisseria gonorrhoeae isolated from patients with disseminated infection are often of the
porin (Por1A) serotype and resist killing by nonimmune normal human serum. The molecular …

We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted
killing by normal human serum and 0/8 serum sensitive strains that bound the complement …

GNA2132 is a Neisseria meningitidis antigen of unknown function, discovered by reverse
vaccinology, which has been shown to induce bactericidal antibodies in animal models. Here …

Neisseria meningitidis and Neisseria gonorrhoeae are Gram-negative pathogenic bacteria
responsible for bacterial meningitis and septicemia, and the sexually transmitted disease …