User profiles for Santi Mestre-Fos

Santi Mestre-Fos

University of California, Berkeley
Verified email at berkeley.edu
Cited by 149

G-quadruplexes in human ribosomal RNA

S Mestre-Fos, PI Penev, S Suttapitugsakul, M Hu… - Journal of molecular …, 2019 - Elsevier
rRNA is the single most abundant polymer in most cells. Mammalian rRNAs are nearly twice
as large as those of prokaryotes. Differences in rRNA size are due to expansion segments, …

[HTML][HTML] Human ribosomal G-quadruplexes regulate heme bioavailability

S Mestre-Fos, C Ito, CM Moore, AR Reddi… - Journal of Biological …, 2020 - ASBMB
The in vitro formation of stable G-quadruplexes (G4s) in human rRNA was recently reported.
However, their formation in cells and their cellular roles were not resolved. Here, by taking a …

[HTML][HTML] A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits

…, P Pollet, B Rothschild-Mancinelli, S Mestre-Fos… - Journal of Biological …, 2020 - ASBMB
Widespread testing for the presence of the novel coronavirus severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID-19 …

[HTML][HTML] Profusion of G-quadruplexes on both subunits of metazoan ribosomes

S Mestre-Fos, PI Penev, JC Richards, WL Dean… - PLoS …, 2019 - journals.plos.org
Mammalian and bird ribosomes are nearly twice the mass of prokaryotic ribosomes in part
because of their extraordinarily long rRNA tentacles. Human rRNA tentacles are not fully …

[PDF][PDF] Depletion assisted hemin affinity (DAsHA) proteomics reveals an expanded landscape of heme-binding proteins in the human proteome

H Kim, CM Moore, S Mestre-Fos, DA Hanna… - Metallomics, 2023 - academic.oup.com
Heme b (iron protoporphyrin IX) plays important roles in biology as a metallocofactor and
signaling molecule. However, the targets of heme signaling and the network of proteins that …

[HTML][HTML] eIF3 engages with 3'-UTR termini of highly translated mRNAs in neural progenitor cells

S Mestre-Fos, L Ferguson, M Trinidad, NT Ingolia… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Stem cell differentiation involves a global increase in protein synthesis to meet the demands
of specialized cell types. However, the molecular mechanisms underlying this translational …

Buzz about RT-qPCR: An RT-qPCR formulation for SARS-CoV-2 detection using reagents produced at Georgia Institute of Technology

…, P Pollet, B Rothschild-Mancinelli, S Mestre-Fos… - 2020 - pesquisa.bvsalud.org
Widespread testing for the presence of the novel coronavirus SARS-CoV-2 in individuals
remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment…

G-quadruplex formation on specific surface-exposed regions of the human ribosomal RNA

S Mestre-Fos, PI Penev, S Suttapitugsakul, C Ito… - bioRxiv, 2018 - biorxiv.org
Profound similarities and critical differences mark ribosomes across phylogeny. The ribosomal
core, approximated by the prokaryotic ribosome, is universal, yet mammalian ribosomes …

G-quadruplexes in ribosomal RNA: an evolutionarily conserved feature of higher eukaryotic ribosomes

S Mestre-Fos, P Penev, C Ito… - The Astrobiology …, 2019 - ui.adsabs.harvard.edu
Ribosomes are the molecular machines responsible for synthesis of all proteins in the cell.
They are made of ribosomal proteins (rProteins) and ribosomal RNA (rRNA). The more than …

[PDF][PDF] Dynamic G-quadruplexes on the surface of the human ribosome

S Mestre-Fos, PI Penev, S Suttapitugsakul, C Ito… - bioRxiv, 2018 - researchgate.net
Substantial similarities and profound differences mark ribosomes across phylogeny. The
ribosomal core is universal, yet mammalian ribosomes are nearly twice as large as those of …