Throughout evolution, organisms have developed immune-surveillance networks to protect
themselves from potential pathogens. At the cellular level, the signalling events that regulate …

Redistribution of specialized molecules in migrating cells develops asymmetry between two
opposite cell poles, the leading edge and the uropod. We show that acquisition of a motile …

A broad array of biological responses, including cell polarization, movement, immune and
inflammatory responses, and prevention of HIV-1 infection, are triggered by the chemokines, a …

HIV‐1 infection triggers lateral membrane diffusion following interaction of the viral envelope
with cell surface receptors. We show that these membrane changes are necessary for …

Signals mediated by chemokine receptors may compete with T cell receptor stop signals
and determine the duration of T cell–antigen-presenting cell interactions. Here we show that …

Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of
host lipid raft–associated receptors, a process that might be linked to Rho guanosine …

Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological
reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial and …

The discoidin domain receptor 2 (DDR2) is a member of a subfamily of receptor tyrosine
kinases whose ligands are fibrillar collagens, and is widely expressed in postnatal tissues. We …

The acquisition of spatial and functional asymmetry between the rear and the front of the cell
is a necessary step for cell chemotaxis. Insulin‐like growth factor‐I (IGF‐I) stimulation of the …

Background ErbB2-positive breast cancer is characterized by highly aggressive phenotypes
and reduced responsiveness to standard therapies. Although specific ErbB2-targeted …