User profiles for Santoshi Muppala
 | Santoshi Muppala PhDScientist Verified email at ccf.org Cited by 1253 |
Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer
Curcumin has promising potential in cancer prevention and therapy by interacting with
proteins and modifying their expression and activity, which includes transcription factors, …
proteins and modifying their expression and activity, which includes transcription factors, …
MicroRNA‐30a inhibits epithelial‐to‐mesenchymal transition by targeting Snai1 and is downregulated in non‐small cell lung cancer
MicroRNAs (miRNAs) are small non‐coding RNAs which regulate gene expression by base‐pairing
to the 3′‐UTR of the target mRNA. Recently, miRNAs have been shown to …
to the 3′‐UTR of the target mRNA. Recently, miRNAs have been shown to …
Thrombospondin-4 mediates TGF-β-induced angiogenesis
TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling
processes. Due to its many functions and cell-specific effects, the consequences of TGF-…
processes. Due to its many functions and cell-specific effects, the consequences of TGF-…
Proangiogenic properties of thrombospondin-4
Objective— Thrombospondin-4 (TSP-4) is 1 of the 5 members of the thrombospondin
protein family. TSP-1 and TSP-2 are potent antiangiogenic proteins. However, angiogenic …
protein family. TSP-1 and TSP-2 are potent antiangiogenic proteins. However, angiogenic …
CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion
P Baumann, W Thiele, N Cremers, S Muppala… - Cellular and Molecular …, 2012 - Springer
Expression of the glycosylphosphatidylinositol-anchored membrane protein CD24 correlates
with a poor prognosis for many human cancers, and in experimental tumors can promote …
with a poor prognosis for many human cancers, and in experimental tumors can promote …
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141
L Naesens, S Muppala, D Acharya, J Nemegeer… - Science …, 2022 - science.org
Herpes simplex virus 1 (HSV-1) infects several billion people worldwide and can cause life-threatening
herpes simplex encephalitis (HSE) in some patients. Monogenic defects in …
herpes simplex encephalitis (HSE) in some patients. Monogenic defects in …
[HTML][HTML] CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a
S Muppala, G Mudduluru, JH Leupold, D Buergy… - PloS one, 2013 - journals.plos.org
Cancer is a complex disease process that evolves as a consequence of multiple malfunctions
in key regulatory molecular networks. Understanding these networks will be essential to …
in key regulatory molecular networks. Understanding these networks will be essential to …
Adiponectin: Its role in obesity-associated colon and prostate cancers
Adipose tissue synthesizes many proteins and hormones collectively called adipokines,
which are linked to a number of diseases, including cancer. Low levels of adiponectin are …
which are linked to a number of diseases, including cancer. Low levels of adiponectin are …
[HTML][HTML] Effects of thrombospondin-4 on pro-inflammatory phenotype differentiation and apoptosis in macrophages
Thrombospondin-4 (TSP-4) attracted renewed attention recently as a result of assignment of
new functions to this matricellular protein in cardiovascular, muscular, and nervous systems. …
new functions to this matricellular protein in cardiovascular, muscular, and nervous systems. …
YAP and TAZ are distinct effectors of corneal myofibroblast transformation
S Muppala, VK Raghunathan, I Jalilian… - Experimental eye …, 2019 - Elsevier
Purpose Transforming growth factor β1 (TGFβ1) is elevated in wounds after injury and
promotes the transdifferentiation of quiescent cells in the stroma (keratocytes, to activated …
promotes the transdifferentiation of quiescent cells in the stroma (keratocytes, to activated …