A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

…, J Beghain, AC Langlois, N Khim, S Kim… - Nature, 2014 - nature.com
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

…, N Khim, S Sreng, P Chim, S Kim… - The Lancet infectious …, 2013 - thelancet.com
Background Artemisinin resistance in Plasmodium falciparum lengthens parasite clearance
half-life during artemisinin monotherapy or artemisinin-based combination therapy. Absence …

[HTML][HTML] A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

…, M Warsame, L Wini, S Zakeri, S Kim… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations …

[HTML][HTML] A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

…, B Saintpierre, J Beghain, S Chy, S Kim… - The Lancet Infectious …, 2017 - thelancet.com
Background Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance
and is facing high rates of dihydroartemisinin–piperaquine treatment failures. Genetic …

Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label …

…, L Song, J Tarning, MC Char, S Kim… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Western Cambodia is recognized as the epicenter of Plasmodium falciparum multidrug
resistance. Recent reports of the efficacy of dihydroartemisinin (DHA)-piperaquine (PP), the latest …

Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia

B Witkowski, N Khim, P Chim, S Kim, S Ke… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The declining efficacy of artemisinin derivatives against Plasmodium falciparum in western
Cambodia is a major concern. The knowledge gap in the understanding of the mechanisms …

[HTML][HTML] Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in …

V Duru, N Khim, R Leang, S Kim, A Domergue… - BMC medicine, 2015 - Springer
Background The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium
falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests …

[HTML][HTML] An innovative tool for moving malaria PCR detection of parasite reservoir into the field

L Canier, N Khim, S Kim, V Sluydts, S Heng, D Dourng… - Malaria journal, 2013 - Springer
Background To achieve the goal of malaria elimination in low transmission areas such as in
Cambodia, new, inexpensive, high-throughput diagnostic tools for identifying very low …

[HTML][HTML] Whole Genome Sequencing of Field Isolates Reveals a Common Duplication of the Duffy Binding Protein Gene in Malagasy Plasmodium vivax Strains

…, C Benedet, A Ratsimbasoa, S Kim… - PLoS neglected …, 2013 - journals.plos.org
Background Plasmodium vivax is the most prevalent human malaria parasite, causing
serious public health problems in malaria-endemic countries. Until recently the Duffy-negative …

[HTML][HTML] Plasmodium knowlesi infection in humans, Cambodia, 2007–2010

N Khim, S Siv, S Kim, T Mueller… - Emerging infectious …, 2011 - ncbi.nlm.nih.gov
Two cases of Plasmodium knowlesi infection in humans were identified in Cambodia by 3
molecular detection assays and sequencing. This finding confirms the widespread distribution …