IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile
inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn’s …

The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …

Nuclear factor (NF)-κB is a transcription factor family which transmits signals from the cell
surface to the nucleus, resulting in transcriptional effects on genes involved in inflammation, …

During experimental cerebral malaria (ECM) mice develop a lethal neuropathological syndrome
associated with microcirculatory dysfunction and intravascular leukocyte sequestration. …

Dendritic cell (DC) differentiation is abnormal in type 1 diabetes mellitus (T1DM). However,
the nature of the relationship between this abnormality and disease pathogenesis is unknown…

About half of the world’s population and 80% of the world’s biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

Objectives The immunologic events that build up to the fatal neurological stage of experimental
cerebral malaria (ECM) are incompletely understood. Here, we dissect immune cell …

The global prevalence of respiratory infectious and inflammatory diseases remains a major
public health concern. Prevention and management strategies have not kept pace with the …

Sequence variation in the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1)
oncogene structure may affect antigen‐presenting cell (APC) function of infected B cells and …

Tuberculosis (TB) is a major global public health problem causing significant mortality and
morbidity. In addition to ~10.4 million cases of active TB annually, it is estimated that about …