Genomic imprinting is a phenomenon that restricts transcription to predominantly one parental
allele. How this transcriptional duality is regulated is poorly understood. Here we perform …

Recently, many advancements in genome-wide chromatin topology and nuclear architecture
have unveiled the complex and hidden world of the nucleus, where chromatin is organized …

The current academic and business landscape does not provide a clear path for doctoral
trainees graduating. Moreover, the fundamental need of the hour is diversification of the …

… Saqib Sachani conceived the project, experiments and wrote the manuscript. 2. Saqib S. …
Mellissa Mann and Saqib Sachani conceived the project, experiments and wrote the manuscript…

… networks involved in vertebrate eye development by Saqib S. Sachani A Thesis Submit …
written permission from the copyright owner(s) to include such material(s) in my thesis and have …

Genomic imprinting is an epigenetic phenomenon, whereby dual chromatin states lead to
expression of one, and silencing of the other parental allele. Recently, we identified a …

Microinjection has a long and distinguished history in Xenopus and has been used to introduce
a surprisingly diverse array of agents into embryos by both intra- and intercellular means…

… Those tasked with making strategic decisions must not only juggle the demands of various
stakeholders, they must also fulfill their agency’s mission. Too often, the leaders of these …

… Although the mechanism(s) targeting macroH2A1 to the ICRs are not well understood at
moment, the allele-specific deposition of macroH2A1 in the ICRs represents another epigenetic …

… manufacturer’s instructions. Bisulfite conversion of 500 ng genomic DNA per sample was
performed with the EpiTect Bisulfite Kit (Qiagen) according to the manufacturer’s specifications. …