Hsp90 is the most abundant molecular chaperone in the eukaryotic cell. One of the most
stringent clients is the glucocorticoid receptor (GR), whose in vivo function strictly depends on …

In eukarya, chaperones Hsp70 and Hsp90 act coordinately in the folding and maturation of
a range of key proteins with the help of several co-chaperones, especially Hop. Although …

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA)
and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. …

Protein secretion and membrane insertion occur through the ubiquitous Sec machinery. In
this system, insertion involves the targeting of translating ribosomes via the signal recognition …

The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein)
is posited as a master regulator of long-term synaptic plasticity and memory. However, the …

The outer-membrane of Gram-negative bacteria is critical for surface adhesion, pathogenicity,
antibiotic resistance and survival. The major constituent – hydrophobic β-barrel Outer-…

The macromolecular machines of life use allosteric control to self-assemble, dissociate and
change shape in response to signals. Despite enormous interest, the design of nanoscale …

Long tail fibers of bacteriophage T4 are formed by proteins gp34, gp35, gp36, and gp37,
with gp34 located at the phage-proximal end and gp37 at the phage-distal, receptor-binding …

Phosphorylated tyrosine hydroxylase (TH) can form complexes with 14-3-3 proteins, resulting
in enzyme activation and stabilization. Although TH was among the first binding partners …

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