See Tracey (doi: 10.1093/brain/aww147 ) for a scientific commentary on this article.
Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute …

In addition to their well-established role in signaling rewarding outcomes and reward-predictive
cues and in mediating positive reinforcement, there is growing evidence that nucleus …

The placebo response is universally observed in clinical trials of pain treatments, yet the
individual characteristics rendering a patient a ‘placebo responder’ remain unclear. Here, in …

Societal implications of technology are often considered after public deployment. However,
broader impacts ought to be considered during the onset and throughout development to …

Experiences and memories are often mismatched. While multiple studies have investigated
psychological underpinnings of recall error with respect to emotional events, the …

Background The nucleus accumbens (NAc) has a well established role in reward processing.
Yet, there is growing evidence showing that NAc function, and its connections to other …

Psychological and personality factors, socioeconomic status, and brain properties all contribute
to chronic pain but have essentially been studied independently. Here, we administered …

The dearth of prescribing guidelines for physicians is one key driver of the current opioid
epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data …

Researchers seeking to examine and prevent technology-mediated harms have emphasized
the importance of directly engaging with community stakeholders through participatory …

The objective of this study is to validate a placebo pill response predictive model—a
biosignature—that classifies chronic pain patients into placebo responders (predicted-PTxResp) …