We report more than 1400 proteins of the secretory-pathway proteome and provide spatial
information on the relative presence of each protein in the rough and smooth ER Golgi …

The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC)
investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets …

High-throughput, ‘omic’ methods provide sensitive measures of biological responses to
perturbations. However, inherent biases in high-throughput assays make it difficult to interpret …

Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-…

Growing evidence supports a role for the unfolded protein response (UPR) in carcinogenesis;
however, the precise molecular mechanisms underlying this phenomenon remain elusive. …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high-…

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow microenvironment, …

DNA methylation plays a critical role in establishing and maintaining cellular identity. However,
it is frequently dysregulated during tumor development and is closely intertwined with …

MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their
modest effects on direct targets, together with their participation in larger regulatory networks…

Low-grade gliomas (LGGs) are the most common childhood brain tumor in the general
population and in individuals with the Neurofibromatosis type 1 (NF1) cancer predisposition …