Primate genomes encode a variety of innate immune strategies to defend themselves
against retroviruses. One of these, TRIM5α, can restrict diverse retroviruses in a species-specific …

Host genomes have adopted several strategies to curb the proliferation of transposable
elements and viruses. A recently discovered novel primate defense against retroviral infection …

A major limitation of high-throughput DNA sequencing is the high rate of erroneous base
calls produced. For instance, Illumina sequencing machines produce errors at a rate of ∼0.1–1 …

We analyze data from the fall 2020 pandemic response efforts at the University of Colorado
Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory …

TRIM5α provides a cytoplasmic block to retroviral infection, and orthologs encoded by some
primates are active against HIV. Here, we present an evolutionary comparison of the TRIM5 …

Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but some non-human
primates exhibit resistance via unknown mechanisms. Innate immune recognition …

Recent studies have identified ancient virus genomes preserved as fossils within diverse
animal genomes. These fossils have led to the revelation that a broad range of mammalian …

Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells,
a process that is fundamental to life. However, TfR1 also facilitates the cellular entry of …

10.7554/eLife.11785.001 Biological factors that influence the host range and spillover of
Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse …

Tripartite Motif (TRIM) ubiquitin ligases act in the innate immune response against viruses.
One of the best characterized members of this family, TRIM5α, serves as a potent retroviral …