User profiles for Sara M. Rolfe
Sara RolfeResearch Scientist, University of Washington Verified email at uw.edu Cited by 299 |
A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex
Hmx1 encodes a homeodomain transcription factor expressed in the developing lateral
craniofacial mesenchyme, retina and sensory ganglia. Mutation or mis-regulation of Hmx1 …
craniofacial mesenchyme, retina and sensory ganglia. Mutation or mis-regulation of Hmx1 …
Analysis of facial skeletal asymmetry during foetal development using μCT imaging
M Katsube, SM Rolfe, SR Bortolussi… - Orthodontics & …, 2019 - Wiley Online Library
Structured Abstract Objectives Asymmetry has been noted in the human craniofacial region
in several pathological conditional and growth abnormalities, often with a directional …
in several pathological conditional and growth abnormalities, often with a directional …
Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish
Due to the complexity of fish skulls, previous attempts to classify craniofacial phenotypes
have relied on qualitative features or sparce 2D landmarks. In this work we aim to identify …
have relied on qualitative features or sparce 2D landmarks. In this work we aim to identify …
ALPACA: a fast and accurate approach for automated landmarking of three-dimensional biological structures
Landmark-based geometric morphometrics has emerged as an essential discipline for the
quantitative analysis of size and shape in ecology and evolution. With the ever-increasing …
quantitative analysis of size and shape in ecology and evolution. With the ever-increasing …
An independent component analysis based tool for exploring functional connections in the brain
SM Rolfe, L Finney, RF Tungaraza… - Medical Imaging …, 2009 - spiedigitallibrary.org
This work introduces a MATLAB-based tool developed for investigating functional connectivity
in the brain. Independent component analysis (ICA) is used as a measure of voxel …
in the brain. Independent component analysis (ICA) is used as a measure of voxel …
Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish mutants
Computational anatomy (CA) approaches start by estimating a canonical ‘template’ from a
sample of images. This template is then used as a basis for statistical analysis to quantify …
sample of images. This template is then used as a basis for statistical analysis to quantify …
A new landmark-independent tool for quantifying and characterizing morphologic variation
This paper develops a landmark-independent, deformable-registration-based framework
that can utilize 3D surface images generated by any multidimensional imaging modality. The …
that can utilize 3D surface images generated by any multidimensional imaging modality. The …
RNA interference therapy in lung transplant patients infected with respiratory syncytial virus
MR Zamora, M Budev, M Rolfe, J Gottlieb… - American journal of …, 2011 - atsjournals.org
Rationale: Lower respiratory tract infections due to respiratory syncytial virus (RSV) are
associated with development of bronchiolitis obliterans syndrome in lung transplant (LTX) …
associated with development of bronchiolitis obliterans syndrome in lung transplant (LTX) …
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
…, JD Eicher, SJ Sharp, J Luan, E De Lucia Rolfe… - Nature …, 2017 - nature.com
Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach, we …
mechanisms underlying this link remain obscure. Using an integrative genomic approach, we …
Staphylococcus aureus adaptation to aerobic low-redox-potential environments: implications for an intracellular lifestyle
BAF Christmas, MD Rolfe, M Rose… - Microbiology, 2019 - microbiologyresearch.org
Methicillin-resistant Staphylococcus aureus is a ‘superbug’ that is responsible for extensive
death and morbidity. Chronic S. aureus infections are associated with the presence of …
death and morbidity. Chronic S. aureus infections are associated with the presence of …