The immune system plays an important role in regulating tumor growth and metastasis.
Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical “…

Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such
as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that …

Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries
characterized by leukocyte accumulation in the vessel wall. Both innate and adaptive immune …

Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4 + T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein B …

Mononuclear phagocytes are a heterogeneous family that occupy all tissues and assume
numerous roles to support tissue function and systemic homeostasis. Our ability to dissect the …

Therapeutic benefit to immune checkpoint blockade (ICB) is currently limited to the subset of
cancers thought to possess a sufficient tumor mutational burden (TMB) to allow for the …

Rationale: CD4 T cells are involved in the pathogenesis of atherosclerosis, but
atherosclerosis-specific CD4 T cells have not been described. Moreover, the chemokine(s) that …

Background Intravascular leukocyte recruitment in most vertebrate tissues is restricted to
postcapillary and collecting venules, whereas capillaries and arterioles usually support little or …

Neutrophils are essential for innate immunity and inflammation and many neutrophil
functions are β 2 integrin-dependent. Integrins can extend (E + ) and acquire a high-affinity …

Rationale: Nonclassical mouse monocyte (CX3CR1 high , Ly-6C low ) patrolling along the
vessels of the microcirculation is critical for endothelial homeostasis and inflammation. …