User profiles for Sara P. Faccidomo

Sara Faccidomo

Assistant Professor, Psychiatry and Alcohol Studies Center, UNC- Chapel Hill
Verified email at med.unc.edu
Cited by 2421

Moderate alcohol drinking and the amygdala proteome: identification and validation of calcium/calmodulin dependent kinase II and AMPA receptor activity as novel …

MC Salling, SP Faccidomo, C Li, K Psilos, C Galunas… - Biological …, 2016 - Elsevier
Background Despite worldwide consumption of moderate amounts of alcohol, the neural
mechanisms that mediate the transition from use to abuse are not fully understood. Methods …

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

…, NA Crowley, JF DiBerto, SP Faccidomo… - Journal of …, 2020 - Soc Neuroscience
The central nucleus of the amygdala plays a significant role in alcohol use and other affective
disorders; however, the genetically-defined neuronal subtypes and projections that govern …

Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice

…, KE Psilos, VR Eastman, SP Faccidomo… - Pharmacology …, 2017 - Elsevier
Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction.
Evidence suggests that reinstatement (eg, relapse), may be regulated by cell signaling …

Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and …

JL Hoffman, SP Faccidomo, SM Taylor… - …, 2023 - Springer
Rationale The development and progression of alcohol use disorder (AUD) are widely
viewed as maladaptive neuroplasticity. The transmembrane alpha-amino-3-hydroxy-5-methyl-4-…

Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and …

JL Hoffman, SP Faccidomo, SM Taylor, KG DeMiceli… - bioRxiv, 2022 - biorxiv.org
Rationale The development and progression of alcohol use disorder (AUD) is widely
viewed as maladaptive neuroplasticity. The transmembrane alpha-amino-3-hydroxy-5-methyl-4-…

Calcium‐permeable AMPA receptor activity and GluA1 trafficking in the basolateral amygdala regulate operant alcohol self‐administration

S Faccidomo, ES Cogan, OJ Hon, JL Hoffman… - Addiction …, 2021 - Wiley Online Library
… (E) Measurement of ethanol dosage (g/kg) showed that mice consumed pharmacologically
meaningful levels of the drug during 1-h sessions as previously shown in Faccidomo et al. (F–…

Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway

S Faccidomo, J Besheer, PC Stanford, CW Hodge - Psychopharmacology, 2009 - Springer
Rationale Extracellular signal-regulated protein kinase (ERK 1/2 ) is a member of the
mitogen-activated protein kinase (MAPK) signaling pathway and a key molecular target for ethanol (…

Aggressive behavioral phenotypes in mice

…, SC Maxson, EW Fish, S Faccidomo - Behavioural brain research, 2001 - Elsevier
Aggressive behavior in male and female mice occurs in conflicts with intruding rivals, most
often for the purpose of suppressing the reproductive success of the opponent. The …

Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253

EW Fish, S Faccidomo, KA Miczek - Psychopharmacology, 1999 - Springer
Rationale: Models of heightened aggression may be particularly relevant in exploring
pharmacological options for the clinical treatment of aggressive and impulsive disorders. …

Regulation of motivation to self‐administer ethanol by mGluR5 in alcohol‐preferring (P) rats

J Besheer, S Faccidomo, JJM Grondin… - Alcoholism: Clinical …, 2008 - Wiley Online Library
Background: Emerging evidence indicates that Group I metabotropic glutamate receptors (mGluR1
and mGluR5) differentially regulates ethanol self‐administration in several rodent …