Directed differentiation protocols enable derivation of cardiomyocytes from human pluripotent
stem cells (hPSCs) and permit engineering of human myocardium in vitro. However, hPSC-…

We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, …

Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an
important therapeutic target population for modeling and treating cardiovascular diseases. …

The primary function of vascular networks is to transport blood and deliver oxygen and nutrients
to tissues, which occurs at the interface of the microvasculature. Therefore, the formation …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor
pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the …

While interstitial fibrosis plays a significant role in heart failure, our understanding of disease
progression in humans is limited. To address this limitation, we have engineered a cardiac-…

Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) offer an
unprecedented opportunity to remuscularize infarcted human hearts. However, studies have shown …

Heart disease is a significant burden on global health care systems and is a leading cause
of death each year. To improve our understanding of heart disease, high quality disease …

We have previously demonstrated that implanted microvessels form a new microcirculation
with minimal host-derived vessel investment. Our objective was to define the vascular …

We describe here a bioreactor capable of applying electrical field stimulation in conjunction
with static strain and on-line force of contraction measurements. It consisted of a …