Single-cell RNA-seq can yield valuable insights about the variability within a population of
seemingly homogeneous cells. We developed a quantitative statistical method to distinguish …

Measurement of the transcriptomes of single cells has been feasible for only a few years, but
it has become an extremely popular assay. While many types of analysis can be carried out …

During early human pregnancy the uterine mucosa transforms into the decidua, into which
the fetal placenta implants and where placental trophoblast cells intermingle and …

The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

Transcription factors are key cellular components that control gene expression: their activities
determine how cells function and respond to the environment. Currently, there is great …

10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …

The development of high-throughput RNA sequencing (RNA-seq) at the single-cell level has
already led to profound new discoveries in biology, ranging from the identification of novel …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as
ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus disease …

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …