In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …

Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …

… Sarah Barrin; Sarah Barrin … Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux,
Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali …

CD8 T cell are key players in the fight against cancer. In order for CD8 T cells to kill tumor cells
they need to enter into the tumor, migrate within the tumor microenvironment and respond …

Immunotherapy has been a revolution in cancer management in the metastatic setting. This
has led to a prompt evaluation of such therapies in earlier stages. This article discusses the …

The immune synapse is a key structure organizing T-cell activation against foreign entities,
such as cancer cells expressing neoantigens. One crucial step in this activation cascade is …

Simple Summary B cells are gaining increasing recognition as important contributors to the
tumor microenvironment, influencing, positively or negatively, tumor growth, patient survival, …

Background: Dendritic cells (DCs) are promising targets for cancer immunotherapies owing
to their central role in the initiation and the control of immune responses. Their functions …

Dendritic cells (DCs) are professional APCs, which sample Ags in the periphery and migrate
to the lymph node where they activate T cells. DCs can also present native Ag to B cells …

Background Although immune checkpoint inhibitors (ICI) have demonstrated their efficacy
in endometrial cancer (EC), mismatch repair deficient/microsatellite instability high (MMRd/MSI…