[HTML][HTML] Open source drug discovery with the malaria box compound collection for neglected diseases and beyond

…, GJ Crowther, N Cowan, S D'alessandro… - PLoS …, 2016 - journals.plos.org
A major cause of the paucity of new starting points for drug discovery is the lack of interaction
between academia and industry. Much of the global resource in biology is present in …

[HTML][HTML] The use of antimalarial drugs against viral infection

S D'Alessandro, D Scaccabarozzi, L Signorini… - Microorganisms, 2020 - mdpi.com
In recent decades, drugs used to treat malaria infection have been shown to be beneficial
for many other diseases, including viral infections. In particular, they have received special …

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

S D'Alessandro, F Silvestrini… - Journal of …, 2013 - academic.oup.com
Objectives Plasmodium gametocytes, responsible for malaria parasite transmission from
humans to mosquitoes, represent a crucial target for new antimalarial drugs to achieve malaria …

Salinomycin and other ionophores as a new class of antimalarial drugs with transmission-blocking activity

S D'Alessandro, Y Corbett, DP Ilboudo… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The drug target profile proposed by the Medicines for Malaria Venture for a malaria
elimination/eradication policy focuses on molecules active on both asexual and sexual stages of …

[HTML][HTML] Oxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO2 Ceramic Tiles

…, N Basilico, S Delbue, S D'Alessandro… - International Journal of …, 2021 - mdpi.com
The current SARS-CoV-2 pandemic causes serious public health, social, and economic
issues all over the globe. Surface transmission has been claimed as a possible SARS-CoV-2 …

Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity

S D'Alessandro, M Gelati, N Basilico, EA Parati… - Toxicology, 2007 - Elsevier
Artemisinin derivatives are highly effective and well-tolerated antimalarial drugs that now
form the basis of antimalarial combination therapies recommended by the World Health …

[HTML][HTML] Effect of hypoxia on gene expression in cell populations involved in wound healing

S D'Alessandro, A Magnavacca, F Perego… - BioMed Research …, 2019 - hindawi.com
Wound healing is a complex process regulated by multiple signals and consisting of several
phases known as haemostasis, inflammation, proliferation, and remodelling. Keratinocytes, …

[HTML][HTML] Total synthesis of the natural chalcone lophirone E, synthetic studies toward benzofuran and indole-based analogues, and investigation of anti-leishmanial …

…, D Taramelli, N Basilico, S D'Alessandro… - Molecules, 2022 - mdpi.com
The potential of natural and synthetic chalcones as therapeutic leads against different
pathological conditions has been investigated for several years, and this class of compounds …

A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays

S D'Alessandro, G Camarda, Y Corbett… - Journal of …, 2016 - academic.oup.com
Objectives As most available antimalarial drugs are ineffective against the Plasmodium
falciparum transmission stages, new drugs against the parasite's gametocytes are urgently …

Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in Plasmodium falciparum transmissible gametocyte …

…, P Smith, S D'Alessandro, D Taramelli… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
The emergence of resistance toward artemisinin combination therapies (ACTs) by the malaria
parasite Plasmodium falciparum has the potential to severely compromise malaria control. …