User profiles for Sarah E. Howie
 | Sarah EM HowieUniversity of Edinburgh Verified email at ed.ac.uk Cited by 10285 |
Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
…, N van Rooijen, C Haslett, SE Howie… - American journal of …, 2011 - atsjournals.org
… (D and E) Further groups of mice were given bleomycin on Day 0 ± LC intraperitoneally on
Days 21, 22, and 23 and culled on Day 28. Saline 0.9% was given intratracheally as a control…
Days 21, 22, and 23 and culled on Day 28. Saline 0.9% was given intratracheally as a control…
Human dendritic cells produce TGF-β1 under the influence of lung carcinoma cells and prime the differentiation of CD4+ CD25+ Foxp3+ regulatory T cells
Dendritic cells (DCs) have a central role in the development of adaptive immune responses,
including antitumor immunity. Factors present in the tumor milieu can alter the maturation of …
including antitumor immunity. Factors present in the tumor milieu can alter the maturation of …
Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell–IL-22 axis
Systemic inflammation, which results from the massive release of proinflammatory
molecules into the circulatory system, is a major risk factor for severe illness, but the precise …
molecules into the circulatory system, is a major risk factor for severe illness, but the precise …
Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells
The gut microbiota fundamentally regulates intestinal homeostasis and disease partially
through mechanisms that involve modulation of regulatory T cells (T regs ), yet how the …
through mechanisms that involve modulation of regulatory T cells (T regs ), yet how the …
Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis
Background Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are both forms of
eczema and are common inflammatory skin diseases with a central role of T cell-derived IL-22 …
eczema and are common inflammatory skin diseases with a central role of T cell-derived IL-22 …
[HTML][HTML] Chlamydia trachomatis infection during pregnancy—Known unknowns
Genital Chlamydia trachomatis infection is the commonest bacterial sexually transmitted
infection worldwide. Infection prevalence peaks in young women aged between 18-25 years. …
infection worldwide. Infection prevalence peaks in young women aged between 18-25 years. …
Purine metabolism controls innate lymphoid cell function and protects against intestinal injury
Inflammatory bowel disease ( IBD ) is a condition of chronic inflammatory intestinal disorder
with increasing prevalence but limited effective therapies. The purine metabolic pathway is …
with increasing prevalence but limited effective therapies. The purine metabolic pathway is …
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4
J O'Grady, AJ Blaikie, SE Howie… - The Journal of …, 1991 - Wiley Online Library
OPD4 is a recently described monoclonal antibody that recognizes a fixation‐resistant 200
kD antigen restricted to a subset of T cells. Immunolabelling with OPD4 in paraffin sections of …
kD antigen restricted to a subset of T cells. Immunolabelling with OPD4 in paraffin sections of …
A Unique Human Alveolar Macrophage Polarization Phenotype Is Associated With Disease Progression In Idiopathic Pulmonary Fibrosis
RESULTS (P= 0.003). There was a trend towards increased expression of CD206 (mannose
receptor) in IPF progressors at baseline, however this was not significant (P= 0.08). CD 206 …
receptor) in IPF progressors at baseline, however this was not significant (P= 0.08). CD 206 …
13 Predictive Toxicology in
This chapter deals with the application of toxicological approaches and concepts in order to
aid in the prediction of toxicity and resultant disease in the lungs. Given the enormous range …
aid in the prediction of toxicity and resultant disease in the lungs. Given the enormous range …