The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus
can spread and the ability of a generally mild infection to induce severe morbidity and …

Background Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed
to estimate the association of treatment success and death with the use of individual drugs, …

Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The endocannabinoid …

The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the
integral membrane enzyme fatty acid amide hydrolase (FAAH). Pharmacological blockade …

The interferon-induced transmembrane protein 3 (IFITM3) gene is an interferon-stimulated
gene that inhibits the replication of multiple pathogenic viruses in vitro and in vivo. IFITM3 is a …

Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades
the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. …

The budding yeast Saccharomyces cerevisiae has been an invaluable model system for the
study of the establishment of cellular asymmetry and growth polarity in response to specific …

To develop an effective and sustainable cell therapy for sickle cell disease (SCD), we investigated
the feasibility of targeted disruption of the BCL11A gene, either within exon 2 or at the …

Background Sputum culture conversion is often used as an early microbiological endpoint in
phase 2 clinical trials of tuberculosis treatment on the basis of its assumed predictive value …

Orchid mycorrhizal fungi have been assumed to supply carbohydrates to the orchid seedlings
with which they are associated. To do this they must be able to utilize a regular source of …