[HTML][HTML] Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies

…, AD Gallagher, J Maharaj, SE McClelland - Chromosome …, 2023 - Springer
Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …

[PDF][PDF] Non-random mis-segregation of human chromosomes

…, DCJ Spierings, E Vladimirou, F Foijer, SE McClelland - Cell reports, 2018 - cell.com
A common assumption is that human chromosomes carry equal chances of mis-segregation
during compromised cell division. Human chromosomes vary in multiple parameters that …

DNA replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses

…, J Wang, MA Boemo, F Foijer, SE McClelland - BioRxiv, 2019 - biorxiv.org
Background We previously showed that a major driver of cancer chromosomal instability (CIN)
is replication stress, the slowing or stalling of DNA replication. However, the precise …

[PDF][PDF] Replication Stress Generates Multiple Distinct Classes of Copy Number Alterations.

…, P Larsson, J Wang, F Foijer, SE McClelland - researchgate.net
Replication stress can drive genetic instability and is associated with chromosomal
instability in cancer and during reprogramming of stem cells, however the exact mechanisms …

Tools of Engagement: The Potential of Theatre Web Sites for Fostering Active Audience Participation

EL McClelland - 2011 - scholarworks.sjsu.edu
This thesis explores whether theatre Web sites contain tools that have the potential to deepen
audience engagement in live performance. By synthesizing data from a variety of scholarly …

[BOOK][B] Pathogen-mediated mechanisms of major histocompatibility complex diversity

EE McClelland - 2003 - search.proquest.com
The genes of the major histocompatibility complex (MHC) play a critical role in immune
recognition by binding and presenting peptide fragments to T cells. Multiple lines of evidence …

[HTML][HTML] Role of chromosomal instability in cancer progression

SE McClelland - Endocrine-related cancer, 2017 - erc.bioscientifica.com
Cancer cells often display chromosomal instability (CIN), a defect that involves loss or
rearrangement of the cell’s genetic material – chromosomes – during cell division. This process …

CIN-ful cancers

H Rajagopalan, C Lengauer - Cancer chemotherapy and pharmacology, 2004 - Springer
Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However,
the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that …

Efficient use of longitudinal CD4 counts and viral load measures in survival analysis

…, J Ding, J Tien, RS McClelland… - Statistics in …, 2012 - Wiley Online Library
CD4 counts and viral loads are dynamic quantities that change with time in HIV‐infected
persons. Commonly used single summary measures, such as viral load set point or early CD4 …

When, if, and how: Young women contend with orgasmic absence

SN Bell, SI McClelland - The Journal of Sex Research, 2018 - Taylor & Francis
… In the current study, intimate justice (McClelland, Citation2010) encourages us to consider
how the discourses surrounding female orgasm have created a set of expectations for young …