This study describes the single-cell landscape of CAFs in pancreatic cancer during in vivo
tumor evolution. A TGFβ-driven, LRRC15 + CAF lineage is associated with poor outcome in …

Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is
essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs …

The Hippo signaling pathway is responsible for regulating the function of TEAD family
transcription factors in metazoans. TEADs, with their co-activators YAP/TAZ, are critical for …

Polarity of the microtubule (MT) cytoskeleton is essential for many cell functions. Cytoplasmic
linker–associated proteins (CLASPs) are MT-associated proteins thought to organize …

Actin filament networks exert protrusive and attachment forces on membranes and thereby
drive membrane deformation and movement. Here, we show that N-WASP WH2 domains …

Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental
development. It is thought to derive from a Ty3-gyspy LTR (long terminal repeat) …

Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy.
Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve …

Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial
dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, …

Introduction Breast cancer, the most common cause of cancer-related deaths worldwide
among women, is a molecularly and clinically heterogeneous disease. Extensive genetic and …

Background Epithelial remodeling, in which apical-basal polarized cells switch to a migratory
phenotype, plays a central role in development and disease of multicellular organisms. …