A small number of signalling pathways are used iteratively to regulate cell fates, cell
proliferation and cell death in development. Notch is the receptor in one such pathway, and is …

The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve such …

Objective: To review structural interventions in public health, identify distinct approaches to
structural interventions, and assess their implications for HIV-prevention interventions. Method…

The cells along the dorsoventral boundary of the Drosophila wing imaginal disc have
distinctive properties and their specification requires Notch activity. Later in development, these …

The Drosophila eye, a paradigm for epithelial organization, is highly polarized with mirror-image
symmetry about the equator. The R3 and R4 photoreceptors in each ommatidium are …

The legs of Drosophila are divided into segments along the proximodistal axis by flexible
structures called joints. The separation between segments is already visible in the imaginal …

A major challenge in cancer genetics is to determine which low-frequency somatic mutations
are drivers of tumorigenesis. Here we interrogate the genomes of 7,651 diverse human …

The Drosophila post-embryonic neuroblasts (pNBs) are neural stem cells that persist in the
larval nervous system where they proliferate to produce neurons for the adult CNS. These …

Notch is the receptor in one of a small group of conserved signaling pathways that are
essential at multiple stages in development. Although the mechanism of transduction impinges …

Histone chaperones are involved in a variety of chromatin transactions. By a proteomics
survey, we identified the interaction networks of histone chaperones ASF1, CAF1, HIRA, and …