Background Over a third of people with Multiple Sclerosis (PwMS) struggle with poor mental
health, which exacerbates physical symptoms and complicates clinical treatment. To …

Ca 2+ is a ubiquitous cellular signal. Altered expression of specific Ca 2+ channels and
pumps are characterizing features of some cancers. The ability of Ca 2+ to regulate both cell …

Increases in intracellular free Ca 2+ play a major role in many cellular processes. The
deregulation of Ca 2+ signaling is a feature of a variety of diseases, and modulators of Ca 2+ …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced by …

The cytotoxic proteases Granzymes A (GzmA) and B (GzmB) are important components of
the arsenal used by cytotoxic immune cells to kill virally infected/damaged cells. Until now, …

Signals from the tumor microenvironment trigger cancer cells to adopt an invasive phenotype
through epithelial–mesenchymal transition (EMT). Relatively little is known regarding key …

Ca 2+ is an essential and ubiquitous second messenger. Changes in cytosolic Ca 2+ trigger
events critical for tumorigenesis, such as cellular motility, proliferation, and apoptosis. We …

The entry of calcium into the mammary epithelial cell from the maternal plasma (ie, calcium
influx mechanisms) during lactation is poorly understood. As alterations in calcium channels …

Peroxisome proliferator–activated receptor (PPAR) α is a ligand‐activated transcription factor
that has been linked with rodent hepatocarcinogenesis. It has been suggested that PPARα …

Calcium signaling is a critical regulator of cell proliferation. Elevated expression of calcium
channels and pumps is a characteristic of some cancers, including breast cancer. We show …