The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed
as therapeutics and are a major contributor to neutralizing antibody responses elicited …

Diagnoses that are both timely and accurate are critically important for patients with life-threatening
or drug resistant infections. Technological improvements in High-Throughput …

10.7554/eLife.34420.001 The immediate evolutionary space accessible to HIV is largely
determined by how single amino acid mutations affect fitness. These mutational effects can shift …

In critically ill patients, the development of pneumonia results in significant morbidity and
mortality and additional health care costs. The accurate and rapid identification of the microbial …

The high-throughput technique of deep mutational scanning (DMS) has recently made it
possible to experimentally measure the effects of all amino-acid mutations to a protein (Fowler & …

Chimeric antigen receptor (CAR) designs that incorporate pharmacologic control are desirable,
however designs suitable for clinical translation are needed. We designed a fully human, …

Mapping polyclonal serum responses is critical to rational vaccine design. However, most
high-resolution mapping approaches involve isolating and characterizing individual antibodies…

It has recently become possible to experimentally measure the effects of all amino-acid point
mutations to proteins using deep mutational scanning. These experimental measurements …

Molecular phylogenetics is often used to estimate the time since the divergence of modern
gene sequences. For highly diverged sequences, such phylogenetic techniques sometimes …