The use of systematic review and meta-analysis of preclinical studies has become more
common, including those of studies describing the modeling of cerebrovascular diseases. …

Animal models are commonly used in brain ageing research. Amongst these, models where
rodents are exposed to d-galactose are held to recapitulate a number of features of ageing …

Interleukin-1 receptor antagonist (IL-1 RA) is an anti-inflammatory protein used clinically to
treat rheumatoid arthritis and is considered a promising candidate therapy for stroke. Here, …

The replicability of research results has been a cause of increasing concern to the scientific
community. The long-held belief that experimental standardization begets replicability has …

Background and Purpose— Poststroke depression is a prevalent complication of stroke with
unclear pathogenesis. The benefits of antidepressants in this context and their effects on …

Oxidative stress contributes to the progression of brain injury following ischemic stroke and
reperfusion. NADPH oxidase is a well‐established source of superoxide in vascular disease, …

We report a systematic review and meta-analysis of research using animal models of
chemotherapy-induced peripheral neuropathy (CIPN). We systematically searched 5 online …

In both the human and animal literature, it has largely been assumed that edema is the primary
cause of intracranial pressure (ICP) elevation after stroke and that more edema equates …

Background Patients undergoing endovascular therapy for acute ischemic stroke may require
general anesthesia to undergo the procedure. At present, there is little clinical evidence to …

Oxidative stress caused by an excess of reactive oxygen species (ROS) is known to contribute
to stroke injury, particularly during reperfusion, and antioxidants targeting this process …