Germline stem cells are defined by their unique ability to generate more of themselves as well
as differentiated gametes 1 . The molecular mechanisms controlling the decision between …

The Caenorhabditis elegans germ line provides an exceptional model for analysis of the
molecular controls governing stem cell maintenance, the cell cycle transition from mitosis to …

In C. elegans, germline mitosis depends on induction by the somatic distal tip cell (DTC)
and on activity of the glp-1 gene. Using antibodies to GLP-1 protein, we have examined GLP-1 …

The Caenorhabditis elegans germ line provides a model for understanding how signaling
from a stem cell niche promotes continued mitotic divisions at the expense of differentiation. …

The C. elegans germ line proliferates from one primordial germ cell (PGC) set aside in the
early embryo to over a thousand cells in the adult. Most germline proliferation is controlled by …

In the C. elegans germline, GLP-1/Notch signaling and two nearly identical RNA binding
proteins, FBF-1 and FBF-2, promote proliferation. Here, we show that the fbf-1 and fbf-2 genes …

Germ cells can divide mitotically to replenish germline tissue or meiotically to produce
gametes. In this article, we report that GLD-3, a Caenorhabditis elegans Bicaudal-C homolog, …

FBF, a PUF RNA-binding protein, is a key regulator of the mitosis/meiosis decision in the
Caenorhabditis elegans germline. Genetically, FBF has a dual role in this decision: it maintains …

In C. elegans, the glp-1 gene encodes a membrane receptor that is required for anterior cell
fates in the early embryo. We report that GLP-1 protein is localized to anterior blastomeres in …

Controls of stem cell maintenance and early differentiation are known in several systems.
However, the progression from stem cell self-renewal to overt signs of early differentiation is a …