Chaste (‘Cancer, heart and soft-tissue environment’) is a software library and a set of test
suites for computational simulations in the domain of biology. Current functionality has arisen …

Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

A wide variety of techniques have been developed to homogenize transport equations in
multiscale and multiphase systems. This has yielded a rich and diverse field, but has also …

Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and
response to treatment of different cancer cell lines. Their popularity is largely due to the …

Successful progression from bench to bedside for regenerative medicine products is
challenging and requires a multidisciplinary approach. What has not yet been fully recognised is …

A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the
functional behaviour of the heart under physiological and pathophysiological conditions. Heart …

We consider laminar high-Reynolds-number flow through a long finite-length planar channel,
where a segment of one wall is replaced by a massless membrane held under longitudinal …

Brain tissue swelling is a dangerous consequence of traumatic injury and is associated with
raised intracranial pressure and restricted blood flow. We consider the mechanical effects …

We present a theoretical description of flow-induced self-excited oscillations in the Starling
resistor—a pre-stretched thin-walled elastic tube that is mounted on two rigid tubes and …

We consider small-amplitude deformations of a long thin-walled elastic tube having an initially
axially uniform elliptical cross section. The tube is subject to an axial pre-stress, and the …