User profiles for Sarah M. Mangiameli
 | Sarah MangiameliMIT Verified email at mit.edu Cited by 483 |
In situ genome sequencing resolves DNA sequence and structure in intact biological samples
INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …
pairs to whole chromosomes. This organization is thought to regulate gene expression and …
[PDF][PDF] Bifunctional immunity proteins protect bacteria against FtsZ-targeting ADP-ribosylating toxins
ADP-ribosylation of proteins can profoundly impact their function and serves as an effective
mechanism by which bacterial toxins impair eukaryotic cell processes. Here, we report the …
mechanism by which bacterial toxins impair eukaryotic cell processes. Here, we report the …
Transcription leads to pervasive replisome instability in bacteria
10.7554/eLife.19848.001 The canonical model of DNA replication describes a highly-processive
and largely continuous process by which the genome is duplicated. This continuous …
and largely continuous process by which the genome is duplicated. This continuous …
[HTML][HTML] The replisomes remain spatially proximal throughout the cell cycle in bacteria
The positioning of the DNA replication machinery (replisome) has been the subject of several
studies. Two conflicting models for replisome localization have been proposed: In the …
studies. Two conflicting models for replisome localization have been proposed: In the …
Photoselective sequencing: microscopically guided genomic measurements with subcellular resolution
In biological systems, spatial organization and function are interconnected. Here we present
photoselective sequencing, a new method for genomic and epigenomic profiling within …
photoselective sequencing, a new method for genomic and epigenomic profiling within …
The bacterial replisome has factory-like localization
DNA replication is essential to cellular proliferation. The cellular-scale organization of the
replication machinery (replisome) and the replicating chromosome has remained controversial…
replication machinery (replisome) and the replicating chromosome has remained controversial…
[PDF][PDF] Vizualizing Repliication Restart Process In Vivo with Single-Molecule Sensitivity
The rapid and faithful replication of the genome is of central importance to cell proliferation.
During this process, the replication machinery (replisome) frequently encounters obstacles, …
During this process, the replication machinery (replisome) frequently encounters obstacles, …
The Structure and Dynamics of the Bacterial Replisome
SM Mangiameli - 2017 - digital.lib.washington.edu
Cellular reproduction relies on DNA replication. Many bacteria, including Bacillus subtilis
and Escherichia coli, possess only a single circular chromosome which is replicated bi-…
and Escherichia coli, possess only a single circular chromosome which is replicated bi-…
Research briefing
S Mangiameli, F Chen - nature.com
Photoselective sequencing is a new method for genomic and epigenomic profiling within
specific regions of a biological specimen that are chosen using light microscopy. This …
specific regions of a biological specimen that are chosen using light microscopy. This …
[PDF][PDF] Direct Visualization of DNA Replication Conflicts in the Bacterial Cell
Transcription-coupled repair (TCR), a subpathway of nucleotide excision repair (NER), has
been known to lead to more efficient repair than the global NER repair (GGR). Here we use …
been known to lead to more efficient repair than the global NER repair (GGR). Here we use …