An intractable challenge in glaucoma treatment has been to identify druggable targets
within the conventional aqueous humor outflow pathway, which is thought to be regulated/…

Key points Endothelial cells employ transient receptor potential isoform 4 (TRPV4) channels
to sense ambient mechanical and chemical stimuli. In retinal microvascular endothelial cells…

The physiological and neurological correlates of plummeting brain osmolality during edema,
traumatic CNS injury, and severe ischemia are compounded by neuroinflammation. Using …

Fluid secretion by the ciliary body plays a critical and irreplaceable function in vertebrate
vision by providing nutritive support to the cornea and lens, and by maintaining intraocular …

Trabecular meshwork (TM) cells are phagocytic cells that employ mechanotransduction to
actively regulate intraocular pressure. Similar to macrophages, they express scavenger …

Postural orthostatic tachycardia syndrome (POTS) is a common autonomic disorder of
largely unknown etiology that presents with sustained tachycardia on standing, syncope and …

The architecture of the vertebrate eye is optimized for efficient delivery and transduction of
photons and processing of signaling cascades downstream from phototransduction. The …

Rats with ventral dentate gyrus (DG) lesions, sham lesions, and controls were run in a runway
for 20 pellets of food. After reaching running speed asymptote, the number of pellets was …

Transduction of mechanical information is influenced by physical, chemical and thermal
cues but the molecular mechanisms through which transducer activation shapes temporal …

… Sarah N. Redmon …