Recent experiments have revealed surprising behavior in the yeast galactose (GAL) pathway,
one of the preeminent systems for studying gene regulation. Under certain circumstances, …

Organisms must carefully control their metabolism in order to survive. On the other hand,
enzymes must adapt in response to evolutionary pressures on the pathways in which they are …

When a cell encounters a new environment, its transcriptional response can be constrained
by its history. For example, yeast cells in galactose induce GAL genes with a speed and …

An appreciation of organismal diversity is a requirement for understanding evolution and
ecology, and can serve as a source of amazement and wonder that inspires students to enjoy …

… This dissertation is primarily the work of Sarah R. Stockwell, and she conceived the
problems and hypotheses, developed the simulations, and wrote the manuscript. She is also …

… This is convenient for our course structure, in which I (Stockwell) teach biodiversity in the
main class throughout the week while student discussion sections meet separately on different …

Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness 1 , 2 , 3 , 4 . A high-mesenchymal cell state …

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous
mycobacteria, are emerging as an important global threat to individuals with cystic …

… We thank members of the Stockwell and Dixon labs for comments on the manuscript. SJD
(1R01GM122923) and BRS (R35CA209896, P01CA087497) are supported by the National …

We implement a strategy for aligning two protein–protein interaction networks that combines
interaction topology and protein sequence similarity to identify conserved interaction …