Delivery of short interfering RNAs (siRNAs) remains a key challenge in the development of
RNA interference (RNAi) therapeutics. A better understanding of the mechanisms of siRNA …

An outstanding question is how cells control the number and size of membrane organelles.
The small GTPase Rab5 has been proposed to be a master regulator of endosome …

Exploring the cell biology of hepatocytes in vitro could be a powerful strategy to dissect the
molecular mechanisms underlying the structure and function of the liver in vivo. However, this …

Most delivery systems for small interfering RNA therapeutics depend on endocytosis and
release from endo-lysosomal compartments. One approach to improve delivery is to identify …

Early disease diagnosis is key to the effective treatment of diseases. Histopathological
analysis of human biopsies is the gold standard to diagnose tissue alterations. However, this …

We aim to understand the role of past and ongoing anthropogenic impacts on genetic
variation patterns at different spatial scales for the dominant tree species European beech (Fagus …

The mechanisms of organ size control remain poorly understood. A key question is how
cells collectively sense the overall status of a tissue. We addressed this problem focusing on …

The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the
energy needs of the organism. Communication between hepatocytes and extracellular …

Despite the ecological and economic importance of European beech (Fagus sylvatica L.)
genomic resources of this species are still limited. This hampers an understanding of the …

Lumen morphogenesis results from the interplay between molecular pathways and mechanical
forces. In several organs, epithelial cells share their apical surfaces to form a tubular …