Background Use of heterologous prime-boost COVID-19 vaccine schedules could facilitate
mass COVID-19 immunisation. However, we have previously reported that heterologous …

Macrophages mediate crucial innate immune responses via caspase-1-dependent
processing and secretion of interleukin 1β (IL-1β) and IL-18. Although infection with wild-type …

Abstract Treatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy.
Until now, predictive biomarkers 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10 and strategies to augment …

Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of proteins or
RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The approach …

Background Older adults (aged ≥70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …

COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …

Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable
tumour control and result in the long-term survival of patients with advanced cancers 1 . …

The mammalian innate immune system uses Toll-like receptors (TLRs) and Nod-LRRs (NLRs)
to detect microbial components during infection. Often these molecules work in concert; …

Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer
but how they function in vivo remains incompletely understood. Here, we combined intravital …

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …