User profiles for Saravana Kumar Kailasam Mani
 | Saravana Kumar Kailasam ManiCedars Sinai Medical Center Verified email at cshs.org Cited by 478 |
PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus–Induced Liver Carcinogenesis
Elucidating mechanisms of hepatitis B virus (HBV)–mediated hepatocarcinogenesis is
needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is …
needed to gain insights into the etiology and treatment of liver cancer. Cells where HBV is …
[PDF][PDF] RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and …
Chronic hepatitis B virus (HBV) infection is a major factor in hepatocellular carcinoma (HCC)
pathogenesis by a mechanism not yet understood. Elucidating mechanisms of HBV‐…
pathogenesis by a mechanism not yet understood. Elucidating mechanisms of HBV‐…
EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes
Background & Aims Hepatocytes in which the hepatitis B virus (HBV) is replicating exhibit
loss of the chromatin modifying polycomb repressive complex 2 (PRC2), resulting in re-…
loss of the chromatin modifying polycomb repressive complex 2 (PRC2), resulting in re-…
[HTML][HTML] Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma
Rationale: RNA helicase DDX5 is downregulated during hepatitis B virus (HBV) replication,
and poor prognosis HBV-related hepatocellular carcinoma (HCC). The aim of this study is to …
and poor prognosis HBV-related hepatocellular carcinoma (HCC). The aim of this study is to …
[HTML][HTML] Hepatitis B virus-associated hepatocellular carcinoma and hepatic cancer stem cells
SKK Mani, O Andrisani - Genes, 2018 - mdpi.com
Chronic Hepatitis B Virus (HBV) infection is linked to hepatocellular carcinoma (HCC)
pathogenesis. Despite the availability of a HBV vaccine, current treatments for HCC are inadequate…
pathogenesis. Despite the availability of a HBV vaccine, current treatments for HCC are inadequate…
Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma
SKK Mani, O Andrisani - Cytokine, 2019 - Elsevier
Chronic Hepatitis B Virus (HBV) infection is linked to hepatocellular carcinoma (HCC)
pathogenesis. The World Health Organization estimates that globally 257 million people are …
pathogenesis. The World Health Organization estimates that globally 257 million people are …
[PDF][PDF] Single-cell profiling of murine bladder cancer identifies sex-specific transcriptional signatures with prognostic relevance
HA Abdel-Hafiz, SKK Mani, W Huang, KH Gouin… - Iscience, 2023 - cell.com
Bladder cancer (BLCA) is more common in men but more aggressive in women. Sex-based
differences in cancer biology are commonly studied using a murine model with BLCA …
differences in cancer biology are commonly studied using a murine model with BLCA …
[HTML][HTML] RNA helicase DDX5 regulates PRC2/HOTAIR function in Hepatitis B Virus infection and hepatocarcinogenesis
Chronic Hepatitis B Virus (HBV) infection is a major factor in hepatocellular carcinoma (HCC)
pathogenesis by a mechanism not yet understood. Elucidating mechanisms of HBV-…
pathogenesis by a mechanism not yet understood. Elucidating mechanisms of HBV-…
RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma
Background and Aims RNA helicase DEAD box protein 5 (DDX5) is downregulated during
hepatitis B virus (HBV) replication, and associates with poor prognosis HBV-related …
hepatitis B virus (HBV) replication, and associates with poor prognosis HBV-related …
Regulation of Stemness and Metabolic Networks by Polycomb Repressive Complex 2 in Hepatitis B Virus mediated Liver Cancer
SKK Mani - 2017 - search.proquest.com
Chronic Hepatitis B Virus (HBV) infection results in liver cancer. Although effective vaccines
are available to prevent HBV infection, current treatment options for 240 million people …
are available to prevent HBV infection, current treatment options for 240 million people …